Seattle Seahawks vs. San Francisco 49ers Odds, Pick, Prediction 9/18/22

The 49ers are -9.5 favorites on BetOnline Sportsbook. The total is set at 41. 5 points. Seattle Seahawks won both games against San Francisco last year.

The Seattle Seahawks beat the Denver Broncos 17-16 in the opening game of the new NFL season. Geno Smith completed 23 of 28 attempts for 195 yards and two touchdowns. Colby Parkinson and Will Dissly were on the receiving end of those TD passes. Rashaad Penny had 60 rushing yards on 12 carries. Jordyn Brooks and Cody Barton combined for 22 tackles and one sack.

49ers lost 19-10 to the Chicago Bears in Chicago. San Francisco had a 10-0 lead in the third quarter, but the Bears scored 19 unanswered points to win. Trey Lance completed just 13 of 28 pass attempts for 164 yards, no touchdowns, and one interception. Deebo Samuel scored the only touchdown for the 49ers. Talanoa Hufanga made 11 tackles. Tight end George Kittle is injured and it's unknown if he'll play against the Seahawks.

Seattle Seahawks are 5-2 ATS in the last 7 games overall and 12-5 AET as a road underdog. Seattle Seahawks vs. San Francisco 49ers is on 9/18/22.

Seattle Seahawks are a home favorite against San Francisco 49ers on 9/18/22.

The Seattle Seahawks are 15-5-1 ATS in the last 21 H2H meetings and 7-3 AET in previous ten H 2H duels in San Francisco. The 49ers lost to Chicago. Seattle beat Denver last week.

Seattle Seahawks and San Francisco 49ers are playing each other on 9/18/22. The total is 41.5 points. Under is 8-2 in the Seahawks’ last ten games as an underdog and 4-0 in San Fran”s last four games vs. NFC rivals.