Seahawks vs. 49ers Picks, Predictions NFL Week 2: Lance to Get Rolling in The Bay

Lance completed 46.4% of his passes in the 49ers' season opener against the Bears. Only three quarterbacks in 49er's history have had a lower completion percentage in their team's season-opener. The 49erns were penalized 12 times for 99 yards.

The 49ers are 9-point favorites against the Seahawks. The Over/Under has dropped from 44 to 40.5.

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Pete Carroll owns Kyle Shanahan and the 49ers. Since Shanahan took over as head coach, he's 2-8 against Carroll and Seahawks. San Francisco struggled in Chicago. Seattle's defense prepared for Wilson on Monday. Geno Smith has been excellent in his last two starts.

Seahawks and the 49ers are playing in the rain. The forecast has rain for the entire game. Seattle and 49er will run the ball as much as possible.

Elijah Mitchell is injured and Jeff Wilson will be the lead back for the 49ers. Wilson rushed for 600 yards and seven touchdowns in 12 games last season. He's fully recovered from the knee injury that kept him out last year.

Seahawks vs. 49ers picks made 9/16/2022 at 9:57 a.m. ET.