Steelers vs. Bills prediction, final injury report and best bet

Kenny Pickett will start at quarterback for the Pittsburgh Steelers against the Buffalo Bills. The game is a big favorite for Buffalo. Pittsburgh is favored by 4 points. The Steelers are expected to score two touchdowns. Buffalo has been known to start slow and settle in after the first quarter. Steelers have averaged 2.5 points in the opening quarter this season. Bills have scored 6 points so far this year. DraftKings offers a chance to win $200 off a successful $5 NFL money line wager at Draft Kings Sportsbook. FanDuel offers up to $1,000 off $500 NFL bet.

Isaiah McKenzie is out for Buffalo Bills. Tremaine Edmunds is injured. Ed Oliver is doubtful. Jordan Phillips is hurt.

Isaiah McKenzie is out with concussion. Tremaine Edmunds is injured, Ed Oliver is hurt and Jordan Phillips is hamstring-bound.

Diontae Johnson, Minkah Fitzpatrick, Cameron Heyward, Terrell Edmunds and Terriell Edmund are injured for Pittsburgh Steelers' game against Buffalo Bills.

Diontae Johnson, Minkah Fitzpatrick, Cameron Heyward, Terrell Edmunds and Terriell Edmund are injured for the game against the Bills.