Thanksgiving Day NFL Picks: Buffalo Bills at Detroit Lions Betting Odds and Best Bets

The Bills and Lions meet at Ford Field on Thanksgiving Day. Buffalo beat the Browns 31-23 and Detroit beat Giants 31, 18. The BetMGM Maryland Bonus Code gives first bet insurance up to $1,000.

Buffalo Bills are playing Detroit Lions on Thanksgiving Day.

Buffalo Bills are playing the Detroit Lions on Thanksgiving Day. Bills' moneyline is $425. Lions' is +350.

Buffalo Bills are playing the Detroit Lions on Thanksgiving Day. The point spread is 9.5.

The Bills are 10-point favorites against the Lions. Buffalo's offense was effective against Cleveland. The Lions have struggled to stop the run and pass this season. Detroit is averaging an NFL-high 454.2 yards per home game. Caesars Sportsbook Maryland offers a promo code for new users. The Bills have the better home field advantage. They score 34 points per game, the only team with more points on their home fields is the Bills (34). Detroit has the second-best home scoring average (31.6). The team is also the most efficient in terms of rushing yards (454).

Bills to score 31-40 points (+150 at DraftKings Sportsbook) and over 32.5 points (-114 on FanDuel Sportsbooks)

Bills should have the luxury of offensive balance in this game. The Lions defense is willing but not always able. Buffalo will put up a fight for three-plus quarters and win with a late touchdown.