Bills vs. Lions Thanksgiving Picks, Predictions: Are We in for a Turkey Day Shootout?

The Buffalo Bills are coming to Detroit for Thanksgiving. The game was moved from Buffalo because of weather. Buffalo is coming off a 31-23 victory over Cleveland. Detroit is in the midst of its first three-game winning streak since 2017. It is also coming from a win over the previously 7-2 New York Giants.

The lookahead line saw the Bills favored by double digits (-10), but the line has moved in Detroit's favor since then. Buffalo has attracted 68% of the bets and 72% the cash. The Over has been the most popular play, with 83% tickets and 73% handle.

Bills vs. Lions is a Thanksgiving Day game.

Lions are favored by 9.5 points over the Bills. Buffalo has a lot of injuries and a packed stadium. Josh Allen is struggling with an elbow injury. PointsBet offers the best value at 9:9. 5.

Buffalo used an uncommonly balanced offense to lead scoring drives on eight of its 10 possessions in Week 11. Detroit is coming off its fifth game this season with 30-plus points and has scored at least 24 in 70% of the contests. The Lions are proving a solid running game will allow them to score points anywhere.

Jamaal Williams is the leading touchdown scorer for the Lions this season. He is third player in Lions history with 12-plus rushing touchdowns in a season, joining Billy Sims and Barry Sanders. Williams has two or more rushing touchdown in five of the first 10 games of a year since LaDainian Tomlinson in 2006. The Bills defense can be beaten up the middle by Williams.

Bills vs. Lions is a Thanksgiving Day game. The picks are made on 11/22/2022 at 6:20 a.m. ET.