Titans vs. Bills Odds & Prediction: Tough MNF Game Against Massive Underdog

Tennessee and Buffalo will play on Monday Night Football in 2022. The Titans have won the last two seasons. Buffalo has won four of the previous five meetings. Tennessee won in 2020 as a three-point home underdog.

Titans vs. Bills is on Monday at 7:15 pm ET.

Bills beat Rams 31-10 last week. Titans lost to New York Giants 21-20. Last year's meeting ended in Titans victory. Bills are double-digit favorites. The Titans are 2-0 straight up. They were 4-1-2 against the spread last season. They beat Baltimore 28-12 in the 2019 postseason. Tennessee's running back Derrick Henry had a good game against Giants.

Titans and Bills play each other on Monday Night Football. The game will be played in Upstate New York. Bills lost three times there last season. Last year, Jonathan Taylor had a season-high 185 yards and four touchdowns against Buffalo.