Top College Football Odds and Best Bets Today (Predictions and Picks for Colorado-USC, East Carolina-Cincinnati)

USC is the biggest name on the card on Friday night, laying 34.5 points against Colorado. East Carolina travels to play Cincinnati in a game that could decide who goes to the Conference Championship game.

Cincinnati is 2-6-1 against the spread this season. The current number of 4.5 is significantly down. Last week Ben Bryant threw for 299 yards and two touchdowns on Navy. ECU allows 264.0 yards per game through the air. East Carolina is 0-5-0 in their last six trips to Western Ohio.

Cincinnati is favored to beat Colorado by 4.5 points. The over is a heavy trend with these two teams. Caleb Williams is one of the best quarterbacks in the country. Colorado is 128th in total defense this season and USC is 95th. Last week, USC allowed 35 points to Cal.

Colorado-USC, East Carolina-Cincinnati and Cincinnati are the top college football games today.