Week 1 NFL picks, odds, 2022 predictions, best bets from top expert: This 3-way football parlay pays out 6-1

Matt Ryan will make his Indianapolis debut against the Houston Texans in the teams' season-opener on Sunday. The game is one of 16 on a loaded Week 1 NFL schedule. Other games include the Cowboys and Buccaneers, and the Broncos and Seahawks. SportsLine's Mike Hartstein has a parlay that pays 6-1. He is 427-344 on NFL side picks and 394-330 against spread.

Hartstein loves the Chargers to cover against the Raiders. Los Angeles is aiming to make the playoffs for the first time since 2018. The team made key additions in the offseason, including Khalil Mack. The offensive line has undergone a major overhaul after the season-ending injury of Brandon Parker and the failure of Alex Leatherwood.

Hartstein has a 3-way football parlay that pays out 6-1. Hartstein also has two other spread picks, including one play fading a team that "could struggle initially."