Week 2 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay returns 25-1

Buffalo is the favorite in the 2018 NFL season opener against Tennessee. Dallas and Cincinnati are looking to bounce back after disappointing losses in Week 1. Las Vegas and Oakland are also looking for a win. SportsLine's advanced model simulates every NFL game 10,000 times and has returned a profit of $7,500 for $100 players on top-rated NFL picks since its inception.

Buffalo is the favorite in the 2022 regular season opener against Tennessee. Dallas vs. Cincinnati and Las Vegas vs Arizona are also big games on the schedule. SportsLine's advanced computer model simulates every NFL game 10,000 times and has made 139-98 straight-up NFL picks since 2017. It beat 94% of CBS Sports Football Pick'em players four times in a row. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1.

Cleveland Browns beat Carolina in Week 1 and New York Jets were beaten by Baltimore. SportsLine's model simulates every game 10,000 times and it's picking Cleveland to win and cover the spread. The model has also picked parlay picks for the other NFL games.

The advanced model predicts a 25-1 parlay for NFL Week 2. It also has a model that says an underdog will win outright.