Week 5 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1

Week 5 NFL picks, odds, and parlays from advanced model: This five-way football parlay returns 25-1. Houston Texans have struggled against AFC South rivals Indianapolis and Tennessee since joining the NFL in 2002. They have a 27-13 record against Jacksonville, but they are 7-point favorites against the Jaguars. SportsLine's model simulates every NFL game 10,000 times and has a reputation for being accurate. It has made 139-103 straight-up NFL bets since 2017.

The advanced model simulates every game 10,000 times and it's high on the Miami Dolphins to win and cover against the New York Jets on Sunday. Teddy Bridgewater will make his first start since signing with Miami in March. Tua Tagovailoa is out with a concussion. Last week, Bridgewater made six of his 14 pass completions to Tyreek Hill for 109 yards. Hill leads the NFL with 477 yards on 31 receptions.

The advanced model predicts a 25-1 parlay for NFL Week 5. It also has a model that backs an underdog to win outright.