Week 16 NFL picks, odds, 2023 best bets from proven model: This 5-way football parlay would pay out 25-1

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Week 16 NFL picks, odds, 2023 best bets from proven model: This 5-way football parlay would pay out 25-1

Trevor Lawerence and the Jacksonville Jaguars (8-6) sit atop the AFC South standings, but they've lost their last three games. The Jaguars will try to get back into the win column when they visit Baker Mayfield and the Tampa Bay Buccaneers as part of the Christmas Eve NFL schedule. According to the latest Week 16 NFL odds, Jacksonville is a one-point underdog on the road. Elsewhere on the Week 16 NFL schedule, Dak Prescott and the Dallas Cowboys will face Tua Tagovailoa and the Miami Dolphins on Sunday. Will Prescott lead his team to victory on the road, or will the Dolphins cover as 1.5-point favorites, one of the slimmest NFL spreads of the week? Before you make any Week 16 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 16 NFL picks at SportsLine.

Top Week 16 NFL picks

After simulating every game 10,000 times, the model is high on the New York Jets (-3) to cover against the Washington Commanders. The Jets have won just four games this season, but all four have been at MetLife Stadium. New York secured a dominant 30-6 win over the Houston Texans in its last home game.

In the victory over Houston, New York's defense wreaked havoc all game long. The Jets recorded four sacks and they enter Sunday's showdown ranked seventh in total defense, giving up just 298.4 yards per game. The Commanders, meanwhile, are giving up 384.5 yards per game on defense, which ranks dead last in the NFL. According to the model, New York's defense will finish with 4.5 sacks and an interception on Sunday, a big reason why the Jets cover the spread well over 50% of the time. See which other NFL parlay picks to make here.

How to make Week 16 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model's Week 16 NFL best bets and parlay at SportsLine

What are the model's top Week 16 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 16 NFL best bets from a model on a 178-129 run on top-rated picks, and find out.