Week 2 NFL props, odds, best bets, AI predictions, picks: Patrick Mahomes over 296.5 passing yards

Christian McCaffrey had 152 rushing yards and a touchdown in a Week 1 win over the Steelers. Now, he'll try to continue his dominance over the division-rival Rams on Sunday. McCaffrey's over/under for total rushing yards opened at 66.5 according to the Week 2 NFL props, a total he's bested in six of his last nine starts with the 49ers. Which side of that line should you target in the NFL player props, and which NFL props should be on your radar as you place your Week 2 NFL bets? Before betting any NFL props for Sunday afternoon games in Week 2, you need to see the Week 2 NFL prop predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop. The AI predictions are determined by statistically learning from each player's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an over bet if a player is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Its under bets cashed at a 67% clip in Week 1, bringing a commanding $4,277 for $100 bettors.

For Sunday afternoon games in Week 2, the model has evaluated the NFL player prop odds and provided prop picks for every available prop market. You can only see the AI player prop predictions for NFL Week 2 here.

Top NFL player prop bets for Week 2

After examining hundreds of NFL player props across the Week 2 Sunday afternoon games, SportsLine AI says Patrick Mahomes goes over 296.5 passing yards.

Mahomes had 10% of his pass attempts dropped and another 19% were off target in a shocking Week 1 loss against the Lions, and it's unlikely that the reigning league MVP will have that combination occur again. Tight end Travis Kelce (knee) is listed as questionable, but coach Andy Reid told reporters that he'll play this week, likely giving Mahomes his biggest target back. 

Dating back to last season, Mahomes has cleared the 300-yard passing mark in nine of his last 13 regular season games. That includes on Nov. 13 of last year, when he threw for 331 yards in the regular season against the Jaguars, his opponent this week. 

Kansas City is just a 3.5-point favorite, so it's unlikely that the Chiefs will pull away in this one. That should keep the passing attack operating for all four quarters, and SportsLine's AI model has Mahomes clearing 300 yards of passing, making the Over 296.5 passing yards the value play. .

How to make NFL player prop bets for Week 2

In addition, SportsLine AI has a shocking prediction for a Lamar Jackson prop and has multiple NFL player prop picks with 4.5-star confidence ratings or better (out of 5). You need to see the model's analysis before making any Week 2 NFL prop bets for Sunday afternoon's games.