Xavier vs. Southern prediction, odds, line: 2022 college basketball picks, Dec. 13 best bets from proven model

Xavier Musketeers are looking to extend their three-game winning streak when they face the Southern Tigers on Tuesday at 7 p.m. ET. Southern has won two of its last three games and is getting ready for its eighth road game of the season. Xavier is 5-4-1 against the spread and 5.2-2 ATS this season, while Southern is 2-5-0. SportsLine's computer simulation model simulates every Division I college basketball game 10,000 times and has returned almost $300 on its recent CBB picks.

Xavier vs. Southern is a college basketball game on December 13th. SportsLine's computer model has made its picks and CBB predictions. The game is expected to be played at Southern's campus.

Xavier vs. Southern is a college basketball game. Xavier is favored by 21 points.

Xavier won the Crosstown Shootout for the fourth straight time on Saturday. Xavier received 26 votes in Monday's latest poll. The Musketeers could jump into the top 25 with a pair of wins this week. Southern is 12-3 in their last 15 games and covered the spread in four of their past six games.

Southern has won four of its last six games. The Tigers have been undervalued in the betting market. Xavier is coming off an emotional rivalry victory. Southern has covered the spread in five of their last seven games, including four out of last five road games and is playing a conference opener later in week.

The model simulating Xavier vs. Southern 10,000 times has picked Southern to win. SportsLine's model is leaning Under on the point total and has a point-spread pick that is hitting in almost 70% of simulations.