49ers vs. Cardinals prediction, odds, line, spread: 2023 NFL picks, Week 18 best bets from computer model

The San Francisco 49ers (12-4) host the Arizona Cardinals (4-12) on Sunday at 4:25 p.m. ET. San Fran can lock up the No. 1 seed in the NFC playoffs with a win and a loss by the Philadelphia Eagles. Arizona is eliminated from postseason contention and is looking forward to the offseason and the 2023 NFL Draft. The 49er's are favored by 14 points. SportsLine's computer simulation model is on a 160-113 run on top-rated NFL picks since the 2017 season.

The model has set its sights on 49ers vs. Cardinals and has made its picks and NFL Week 18 predictions. The model is using the following odds and betting lines: 49er's vs Cardinals is a 49-14 spread, over/under 39.5 points and money line: San Francisco -1100, Arizona +700.

49ers vs. Cardinals is a game with a total of 39.5 points. The line is San Francisco -14, Arizona -700.

The 49ers are on a nine-game winning streak. They can clinch the No. 1 seed in the NFC with a win over Arizona. Arizona is without All-Pro wide receiver DeAndre Hopkins and will start its fourth quarterback of the season in David Blough.

Arizona lost 20-19 to the Atlanta Falcons. The Cardinals are playing San Francisco. San Fran ranks first in the NFL in points allowed and rushing yards allowed per game. Arizona is third worst in league in touchdowns allowed with 45 on the season.

The model simulates 49ers vs. Cardinals 10,000 times and has generated a point-spread pick that is hitting in well over 50% of simulations.