49ers vs. Cardinals prediction, odds, line, spread: 2023 NFL picks, Week 18 best bets from proven model
The San Francisco 49ers (12-4) take on the Arizona Cardinals (4-12) in a Week 18 NFC West clash on Sunday at 4:25 p.m. ET. San Fran is favored by 14.5 points. Arizona is 8-8 and San Fransisco is 10-6 against the spread this season. Deebo Samuel is expected to return to action for the 49er. SportsLine's computer simulation model has returned over $7,000 in profit for $100 players on top-rated NFL picks since it was launched in 2017.
The model has set its sights on 49ers vs. Cardinals and has made its picks and NFL Week 18 predictions. The model is using the following odds and betting lines: 49er's vs Cardinals spread: -14.5, over/under: 39.
49ers vs. Cardinals is a game with a spread of 14.5 points. The money line is San Francisco -1100 and Arizona -700.
The 49ers are on a nine-game winning streak and they are playing for the No. 1 seed in the NFC. They beat the Las Vegas Raiders 37-34 in overtime. The Cardinals are banged up and their season is in jeopardy.
Arizona lost 20-19 to the Atlanta Falcons. The Cardinals are playing San Francisco. San Fran ranks first in the NFL in points allowed and rushing yards allowed per game. Arizona is third worst in league in touchdowns allowed with 45 on the season.
The model simulates 49ers vs. Cardinals 10,000 times and it has generated a point-spread pick that is hitting in well over 50% of simulations.
