2022 MLB odds, picks, bets for Saturday, April 16 from proven model: This four-way parlay pays over 12-1

Houston is a -150 favorite against Seattle in Saturday's game at 9:10 p.m. ET. The Rockies are -130 favorites against the Cubs at 8:30 p.,m., but Chicago won the series opener on Thursday. SportsLine's advanced computer model simulates every game 10,000 times and has returned over $900 for $100 players. It has four confident MLB bets for Saturday night.

SportsLine's proven model simulates each of Saturday's games 10,000 times and likes Seattle and Houston to go over 7.5 runs in the Mariners vs. Astros game. Seattle's offense was firing on all cylinders on Friday, scoring 11 runs on 13 hits against Houston. SportsLine model has this game going over the total in more than 60 percent of simulations.

The model has selected a four-way parlay with a payout of over 12-1. SportsLine's model also has three other best bets for Saturday.