2023 MLB picks, odds, best bets for Monday, May 22 from proven model: This three-way parlay pays almost 10-1

The surging San Francisco Giants visit the Minnesota Twins on Monday to kick off a three-game set. First pitch is scheduled for 7:40 p.m. ET from Target Field. The Giants (22-24) have won five of six to surge into the NL West race, currently six games behind the rival Los Angeles Dodgers. They are coming off a 5-1 homestand that included a sweep of the Philadelphia Phillies and taking two of three from the Miami Marlins. The Twins (25-22) have lost four of their past six but still maintain a 3.5-game lead over the Detroit Tigers in the AL Central race.

Monday's matchup features standout starting pitchers. The Giants are scheduled to send out right-hander Alex Cobb (3-1, 1.94 ERA), who is 1-0 with a 2.14 ERA in four road starts. He will be opposed by right-hander Bailey Ober (3-0, 1.78), who has allowed six total earned runs in five starts this season. The Twins are -155 favorites (risk $155 to win $100), while the Giants return a price of +130 in the latest Caesars Sportsbook MLB odds. The over/under for total runs scored is 9. That's one of a dozen games on the Monday MLB schedule. Before making any MLB picks for Monday, be sure to .

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 26-17 roll on all-top rated MLB picks (+379). Anybody who has followed it has seen profitable returns.

Now, the model has locked in three confident MLB best bets for Monday. They all involve games starting at 7:40 p.m. ET or later, so there's plenty of time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of nearly 10-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

After simulating every game on Monday 10,000 times, the model is picking the Oakland Athletics to cover the run line (+1.5, +130) against the Seattle Mariners. The model seeks Oakland keeping this a one-score game in nearly 60% of simulations. First pitch is set for 9:40 p.m. ET from T-Mobile Park.

Although it is well known that the moribund Athletics (10-38) are again in full rebuild mode, the model sees value in pocketing the 1.5 runs while still receiving a plus-money payback. The slumping Mariners (22-24) have lost four of their past six and are 1-5 in their past six Monday games.

Oakland starter Kyle Muller (1-3, 7.71) has been effective in his last two road starts, going 1-1 while striking out seven and allowing two home runs. The A's offense was the culprit in a three-game weekend sweep at the hands of the Astros, plating just three total runs. But the pitching was solid, holding Houston to 10 total runs in the series. See who else to back here.

How to make MLB parlays for Monday

The model has locked in two other best bets for Monday, including a play on a plus-money underdog. You can only see the model's MLB parlay picks at SportsLine.