Best NFL football knockout, survivor pool picks, strategy, advice for Week 1, 2022: Dodge the Bengals

The Cleveland Browns are 4.5-point road favorites over the Carolina Panthers in the lookahead NFL odds from Caesars Sportsbook. Heavy movement is commonplace early in NFL season. SportsLine Projection Model simulates every NFL game 10,000 times and has won over $7,500 for $100 players on top-rated NFL picks since its inception. It hasn't missed a top pick since Week 15 last season and is on a 138-97 run on straight-up NFL predictions.

The model is shying away from the Cincinnati Bengals for the 2022 NFL season. The Bengals are the reigning AFC champions and are favored at home over the Pittsburgh Steelers. Mike Tomlin is 23-8 against the Bengals all-time.

SportsLine's model is backing a team that made a quarterback change in the offseason and has had plenty of success against its Week 1 opponent.