Week 3 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay returns 25-1

The Miami Dolphins are 4.5-point underdogs when they host Buffalo in the Week 3 NFL schedule. Tampa Bay is a 3-1 favorite against Green Bay and Arizona is 4-points underdog to the Rams. SportsLine's computer model simulates every NFL game 10,000 times and has made 139-102 straight-up NFL picks since 2017. It beat 94% of CBS Sports Football Pick'em players four times in a row.

The advanced model simulates every NFL game 10,000 times and has high expectations for the Cincinnati Bengals. The model has the Bengals covering the spread almost 60% of the time. The Jets have already faced one quality opponent this season, getting blown out by Baltimore in Week 1.

The advanced model predicts a 25-1 parlay for the NFL's Week 3. It also backs a shocking team even though they were dominated last week.