Week 13 NFL picks, odds, 2023 best bets from advanced model: This five-way football parlay would pay out 25-1

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Week 13 NFL picks, odds, 2023 best bets from advanced model: This five-way football parlay would pay out 25-1

We've just reached the Week 13 NFL schedule, but there is already a postseason clinching scenario for the Eagles. The simplest clinching scenario involves Philly defeating the 49ers and the Rams losing to the Browns. However, neither of those would be easy tasks since San Fran has the top scoring defense, while Cleveland owns the No. 1 total defense. San Francisco is a three-point road favorite over Philly in the latest Week 13 NFL odds, while the Rams are favored by four at home over the Browns.

With both the Eagles and Browns being underdogs, you could also return a serious profit by backing them with your NFL bets and NFL parlay picks. Before you make any Week 13 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season and is 22-8 straight-up the last two weeks.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 13. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 13 NFL picks at SportsLine.

Top Week 13 NFL picks

After simulating every game 10,000 times, the model is high on the Pittsburgh Steelers (-6.5) to cover at home against the Arizona Cardinals. Flying across the country to play a road game is tough for any team, but it should be especially so for the Cardinals, who have lost their last 10 games away from State Farm Stadium. Meanwhile, the Steelers are coming off their first game under interim OC Eddie Faulkner, and Pittsburgh achieved the type of offensive success it hadn't seen in years. The Steelers gained 421 yards of total offense in last week's win over Cincinnati, ending a 58-game streak of being held under 400 total yards.

QB Kenny Pickett is protecting the ball. He has seven straight starts without a turnover, which is tied for the fifth-longest streak by any QB since 1991. Pittsburgh having extra offensive possessions is bad news for a Cardinals' team that ranks 31st in scoring defense and dead-last in third-down defense. The model knows the Cardinals have an uphill battle in front of them, but it has Arizona coming up well short and losing by double-digits. Pittsburgh is projected to cover in 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 13 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including two underdogs that win outright. You can only see the model's NFL Week 13 best bets and parlay at SportsLine

What are the model's top Week 13 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 13 NFL best bets from a model on a 175-126 run on top-rated picks, and find out.