Lions vs. Jaguars prediction, odds, line, spread: 2022 NFL picks, Week 13 best bets by proven simulation model

The Detroit Lions host the Jacksonville Jaguars in a cross-conference NFL Week 13 game on Sunday at 1 p.m. ET. Detroit is 2-4 at home, while Jacksonville is 1-5 on the road. The latest Lions vs. Jaguars odds from Caesars Sportsbook list this game as a pick'em. SportsLine's computer simulation model is up well over $7,000 for $100 players on top-rated NFL picks since its inception.

Lions vs. Jaguars is a Week 13 NFL game. The game is scheduled for Sunday, September 30. There are several NFL betting lines for the game, including a PK spread and a 51-point over/under.

Lions vs. Jaguars is a game with 51 points. The money line is Detroit -110, Jacksonville - 110.

Detroit Lions lost 28-25 to Buffalo Bills last week. The Lions have won three of their last four games. Jared Goff has been solid this season, completing 232 of 364 passes for 2,682 yards, 17 touchdowns, seven interceptions and a quarterback rating of 93.5.

Jacksonville Jaguars beat Baltimore Ravens 28-27 last week. Trevor Lawrence passed for three touchdowns and 321 yards on 37 attempts. Lawrence has shown improvement under new head coach Doug Pederson.

The model simulates Lions vs. Jaguars 10,000 times and it has picked the Under on the point total.