Cardinals vs. Pirates odds, prediction, line: 2022 MLB picks, Sunday, May 22 best bets from proven model

The Pittsburgh Pirates and St. Louis Cardinals are playing a game at PNC Park on Sunday at 11:35 a.m. ET. The Cardinals won the first two games of the three-game set. St Louis is a -154 favorite on the money line and the over-under is 8.5. SportsLine's advanced computer model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season.

SportsLine's model has set its sights on Cardinals vs. Pirates and has made its picks and MLB predictions. Cardinals are 12-10 in road games and 9-12 in home games.

Cardinals are 12-10 in road games and 9-12 in home games.

The Cardinals have the better offense in this head-to-head matchup. St. Louis is in the top three of the NL in batting average, doubles, and on-base percentage. Pittsburgh is dead-last in NL with 129 runs scored. Pirates rank in bottom two of league with 30 home runs, 51 doubles and .293 on base percentage, .348 slugging percentage and 30 runs.

Pittsburgh is playing against the Cardinals on Sunday. Steven Matz is facing an offense that has a lot of potential. The Pirates have a good walk rate and a low home run rate. St. Louis has an average home runs and walk percentage.

Cardinals vs. Pirates is Sunday, May 22.