Cavaliers vs. Pistons prediction, odds, line: 2022 NBA picks, Feb. 24 best bets from model on 69-41 run

Cleveland Cavaliers host Detroit Pistons at 7 p.m. ET on Thursday. Darius Garland and Caris LeVert are out for Cleveland, but Lauri Markkanen is probable. Caesars Sportsbook lists Cleveland as a seven-point road favorite. The over-under is 209 in the latest Cavaliers vs. Pistons odds. SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,00 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons.

Cleveland Cavaliers host Detroit Pistons on February 24th. The Cavaliers are 20-11-2 against the spread in conference games. Detroit is 16-16 against-the-spread in such games so far.

Cleveland Cavaliers are 20-11-2 against the spread in conference games. Detroit Pistons are 16-16 against-the-spread in the conference.

Cleveland's defense is in the NBA's top tier. Detroit's offense is scuffling. The Cavaliers are shooting 46.6 percent from the field this season. Cleveland is No. 8 in assists (25.3 per game) and in 10th place in offensive rebound rate (27.9 percent).

Detroit's defense is opportunistic and effective. Pistons force 15.2 turnovers per game and create 7.7 steals per contest. Detroit is in the top 10 of the league in second-chance points allowed (12.5 per games) and stops transition effectively (11.6 fast-break points per match). Cleveland's offense ranks below the NBA average in points and points scored per possession. Cavaliers' primary weakness is ball security.

SportsLine's model is leaning under on the total and projects 208 combined points for Cavaliers vs. Pistons. One side of the spread is hitting well over 60 percent of time.