Celtics vs. Trail Blazers odds, line, spread: 2022 NBA picks, Jan. 21 predictions from proven model

The Boston Celtics take on the Portland Trail Blazers at 7:30 p.m. ET on Friday at TD Garden. Boston is favored by eight points. The Celtics are 23-23 overall and 15-9 at home, while Portland is 18-26 overall, 4-15 on road. SportsLine's advanced computer model simulates every NBA game 10,000 times and has returned well over $10,00 in profit on its top-rated NBA picks over the past three-plus seasons.

SportsLine's model has set its sights on Celtics vs. Trail Blazers. The model is using its advanced technology to pick the winner.

Celtics lost to Charlotte on Wednesday. They have won five of their last seven games. Marcus Smart and Robert Williams III could be back in the lineup on Friday. Celtics have beaten Portland in 12 of last 17 home games against them.

Portland Trail Blazers lost 104-92 to the Miami Heat on Wednesday. Anfernee Simons had another great outing, scoring 27 points and dishing out seven assists. CJ McCollum added 24 points in his second game back after a six-week absence due to a lung injury.

Celtics vs. Trail Blazers is a 2018 NBA game. SportsLine's proven model simulates the game 10,000 times and it picks Celtics. The model has covered the spread almost 70 percent of the time.