Chicago White Sox at Cleveland Indians odds, picks and best bets

The Chicago White Sox (34-21) have lost three in a row, but they are still a half-game ahead in the American League Central. The third-place Cleveland Indians (31-24) are trying to complete a sweep of the White Sells. Wednesday's game starts at 6:10 p.m. ET at Progressive Field.

Lucas Giolito and Shane Bieber are the starting pitchers for Wednesday's game. Bieber has a 3.27 ERA and 53 strikeouts in 44 innings against the White Sox. Gio has faced the Indians twice this season. He has surrendered three runs in his last two starts. He allowed three or more in each of his first nine starts, but only once in the previous nine.

Giolito has made just four road starts this season, but has been dominant in that small sample. He has whiffed 32 batters in 23 innings while posting a 2.74 ERA. Giolitto has faced the Indians twice this year, and he has surrendered just two earned runs in 13 innings.

Bieber has a 3.27 ERA in seven career starts against the White Sox. Bieber has had a rough patch in his last two starts, but he has also surrendered three homers in those two games.

Yasmani Grandal, Leury Garcia, Alex Colome, Evan Marshall and Evan Masher are injured.

Chicago White Sox and Cleveland Indians are playing a game. Chicago White Sides are 6th in runs per game and 8th against right-handed pitchers. Cleveland Siders are bottom six in both categories. The total is low for good reason. The winning $10 bet on the WhiteSides will profit $14.