Cleveland Guardians vs San Francisco Giants 4/16/22 MLB Picks, Predictions, Odds

Cleveland Guardians and San Francisco Giants meet in MLB action from Progressive Field on Saturday. On Friday in the opener, the Giants pulled off a three-run victory. Cal Quantrill is taking the mound for Cleveland. The Giants are 49-21 in their last 70 games against right-handed pitchers. Cleveland is 2-5 in its last seven Saturday games. The over is 6-1 in Cleveland’s last 7 games in a series.

Quantrill put up a solid line in his debut (two earned in 5.0 innings) and is off to a good start. DeSclafani had some ups and downs on the eight hits in 3.2 innings during his debuts. Andrew's free pick is Cleveland Guardians +115.