MLB Odds: Giants-Guardians prediction, odds and pick

The San Francisco Giants take on the Cleveland Guardians on Saturday evening. The Giants are currently in a three-way tie for first place in the NL West. Giants will send out Anthony DeSclafani, who has a 4.91 ERA and five strikeouts from his debut start last week against Miami.

The Giants are 5-2 after a good start to the 2022 season. They have the second-best ERA in the majors at 2.39. Their starting pitching has been able to pitch late into games with three quality starts so far. Brandon Belt is on a tear, hitting .368 with an OPS of 1.237. The Giants have a lineup filled with exciting prospects and veterans. They are eighth in MLB in slugging percentage at .414. San Francisco and the Cardinals are playing each other on Saturday.

Cleveland Guardians lost their home opener to the Giants. The team is very good on the field, especially in the hitting department. Cal Quantrill is going to start for the Guardians. The game is a potential classic. Giants are the favorite. They have won all seven games so far. Cleveland has won just one. It is the third time in seven years that the team has lost a home game.

The Giants might have been able to cover the spread in the series premiere yesterday, but they won't be able do it again.