College football odds, lines, spreads: Picks, predictions, betting advice for Week 10, 2023 from proven model

The Week 10 college football schedule features four top-25 matchups, headlined by a pair of SEC showdowns. No. 1 Georgia is a 16-point favorite against No. 14 Missouri in the Week 10 college football odds from SportsLine consensus, while No. 8 Alabama is a 3.5-point favorite against No. 13 LSU. The other top-25 matchups are No. 7 Texas (-5) vs. No. 25 Kansas State and No. 24 USC (+4) vs. No. 5 Washington. There are several other games with College Football Playoff implications as well, including No. 4 Florida State (-21) at Pittsburgh. 

Before making any college football picks for those games or others in Week 10, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 10 game, and the results are in. 

One of the college picks the model is high on during Week 10: Utah (-11) bounces back against Arizona State at 2 p.m. ET on Saturday afternoon. The Utes are coming off a disappointing loss to Oregon, but that has created value in this matchup. Arizona State had lost six straight games prior to its win over Washington State last week, and the Sun Devils lost to Utah by three touchdowns last year. The model expects a similar result on Saturday, as the Utes are covering the spread in more than 70% of simulations. 

Another prediction: No. 1 Georgia (-16) cruises to another blowout win against Missouri in a 3:30 p.m. ET kickoff. The Bulldogs have put together some of their best performances in recent weeks, blowing out Kentucky, Vanderbilt and Florida in consecutive outings. They were 14-point favorites in their 43-20 win against Florida, finishing with nearly 500 total yards. Missouri has not faced a defense this strong all year, which is one reason why Georgia is covering the spread well over 60% of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple underdogs to win outright!