College football odds, lines, spreads: Picks, predictions, betting advice for Week 1, 2023 from proven model

The 2023 college football season began with a seven-game slate last week, but it will really pick up with the Week 1 college football schedule this week. No. 14 Utah hosts Florida to get the action started on Thursday night, while No. 1 Georgia, No. 2 Michigan and No. 3 Ohio State are among the teams in action on Saturday. No. 8 Florida State faces No. 5 LSU in Orlando on Sunday night at 7:30 p.m. ET, and the Week 1 college football games conclude when No. 9 Clemson travels to Duke on Monday night. 

Before making any college football picks for those games or others in Week 1, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 1 game, and the results are in. 

One of the college picks the model is high on during Week 1: Colorado stays within the spread as a 21-point underdog at TCU on Saturday at noon ET. The Buffaloes have a wealth of talent under new head coach Deion Sanders, who led Jackson State to two straight SWAC championships. They are covering the spread in well over 60% of the model's latest simulations. 

Another prediction: Western Kentucky cruises to a blowout win as an 11.5-point home favorite against South Florida on Saturday at 3:30 p.m. ET on CBS Sports Network. The Hilltoppers finished in the top three in Conference USA in points allowed and yards allowed per game last year, finishing 9-5 overall in their fifth season under head coach Tyson Helton. They are covering the spread in well over 70% of the model's latest simulations.  

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple underdogs to win outright!