College Football Week 4 Picks, Predictions & Other Early Lines To Back Today
Stock the coolers, fire up the grill, and grab the nearest ticket or couch. The Week 4 action is truly as good as it gets.
The board is glorious with six top-25 matchups – beginning with No. 19 Colorado taking on No. 10 Oregon in a game that was flexed to a noon kickoff and concluding with No. 9 Ohio State hosting No. 6 Ohio State in an electric nonconference matchup.
These many top-25 games are extremely rare in September, and the for Week 4 promise to deliver one of the best days of the year on the with nonstop action across the country.
College Football Week 4 Spreads
College Football Week 4 Best Bets
Florida State (-1.5) at Clemson
The Seminoles hype train nearly went completely off the rails Saturday, with Florida State surviving in a 31-29 win over Boston College. Clemson is still a home underdog for this week’s matchup, but the Tigers are getting less than a field goal, and this suddenly looks like a very competitive conference game.
Clemson has done all it can after a 28-7 loss at Duke in Week 1, responding with blowout wins over Charleston Southern and Florida Atlantic.
This is now a huge spot for both teams – Clemson is likely out of the ACC title picture with a second conference loss, and the Seminoles still have legit College Football Playoff Aspirations.
Best Bet: TBD
Colorado at Oregon (-20.5)
This is Game of the Week material on paper, with two unbeaten, top-25 conference opponents squaring off in Eugene. Oddsmakers see it as more of a blowout. The Ducks are three-touchdown favorites after a 3-0 start, with wins over Portland State, Texas Tech and Hawaii.
The Buffaloes escaped with a 43-35 double-overtime home win over rival Colorado State last week, a game in which they were favored by 24 points. They’ll also be without two-way star Travis Hunter for a few weeks after he was injured by a dirty hit early against the Rams.
This is the third time in four weeks Colorado’s point spread has been higher than 20 points – twice in favor of the opponent. They pulled off the massive upset the first time around over TCU, but it might take an even better showing to hang with Oregon at Autzen Stadium.
Best Bet: TBD
UCLA at Utah (-4.5)
Another Game of the Week candidate here on an absolutely loaded Saturday, with the Bruins heading to Salt Lake City to take on the Utes.
Both teams are 3-0 and have gotten there with varying levels of dominance – the Bruins weren’t exactly overpowering in a Week 1 win over Coastal Carolina, but they’ve since dispensed of San Diego State and North Carolina Central with ease.
The Utes had ugly but quality wins over Florida and Baylor ahead of a 31-7 victory over Weber State Saturday. They’re still the favorite here, but oddsmakers have it less than a touchdown.
The Bruins offense has put up some seriously impressive numbers and we’ll see if they can maintain with a big step up in competition coming.
Best Bet: TBD
Ole Miss at Alabama (-7)
Few could have predicted the betting line would be in single digits, but here we are after a brutally disappointing start for the Crimson Tide. They got handled at home by Texas and were tied with South Florida, 3-3, at halftime Saturday before pulling away for a 17-3 win. Uncharacteristic, to say the least.
While the Crimson Tide have failed to get the passing game going, the Rebels are throwing for nearly 350 yards per game with impressive back-to-back wins over Tulane and Georgia Tech.
It’s hard to understate the importance of this game for Alabama, given what another upset loss would mean for the future of the program. But the Rebels are dangerous and desperate to snap a seven-game losing streak against the Tide.
Best Bet: TBD
Oregon State (-2.5) at Washington State
Betting shops are expecting a barnburner, with Oregon State favored by less than a field for a huge matchup at Washington State. Both teams are unbeaten at 3-0 and they’re all big ones from here, with the Pac-12 looking more competitive than it’s been in years.
The Beavers have won 10 of their last 11 games dating back to last season, but the Cougars mean business – they’re averaging nearly 400 passing yards per game and QB Cameron Ward has already thrown for nine touchdowns with no interceptions on the year.
Best Bet: TBD
Texas (-15.5) at Baylor
Texas is up to No. 3 in the AP Top 25 rankings after a business-like 31-10 win over Wyoming. It was an impressive showing from a team coming off that massive upset win over the Tide. A sign of maturity and potentially a good indicator for what’s to come.
The Longhorns are giving more than two touchdowns here against a reeling Baylor program. The Bears dropped a pair of games to Texas State and Utah before a Week 3 win over Long Island.
It’s not all bleak – Texas is the lone ranked opponent left on the schedule, so there’s still time to turn things around. That starts with a competitive showing against the Longhorns.
Best Bet: TBD
Ohio State (-3.5) at Notre Dame
This line was available at Notre Dame +10.5 back in August, but it’s gone down a full touchdown after three weeks. Both teams are undefeated, and the Buckeyes got it rolling on offense with a 63-10 win over Western Kentucky on Saturday.
It just hasn’t looked like the dominant Ohio State team we’ve come to expect year in and year out through three weeks.
The Irish look even better than expected at 4-0, and they took the Buckeyes to the wire in a 21-10 loss last season in Columbus. Now they’ve got them in South Bend and can start talking CFP with an upset victory.
Best Bet: TBD
Iowa at Penn State (-14.5)
The Nittany Lions are giving two touchdowns at home after a dominant start to the season, with decisive wins over West Virginia, Delaware and Illinois.
They’re good everywhere, balanced offensively and strong throughout the defense. But the Hawkeyes defense means business and Iowa actually moved the ball for the first time in recent memory Saturday, scoring a 41-10 win over Western Michigan.
That was the first time Iowa had hung 40+ points since a 51-14 win at Maryland on Oct. 1, 2021, so the Hawkeyes will take it. But they need to see continued progress to avoid any uncomfortable conversations.
