Cubs vs. Brewers odds, line, prediction: 2022 MLB Opening Day picks, best bets from proven computer model

Milwaukee Brewers begin their quest for a fifth consecutive postseason appearance when they open the 2022 MLB season against the host Chicago Cubs on Thursday's Opening Day. Milwaukee won the National League Central last season and matched the second-highest win total in franchise history with 95. Chicago had their first losing season since 2014 with a 71-91 record.

Milwaukee Brewers are a one-point favorite against Chicago Cubs. The Brewers' pitching staff led the majors with 1,618 strikeouts last season. Chicago is 5-22 in their last 27 games as home underdogs.

Cubs vs. Brewers money line is Milwaukee -180, Chicago +160. The Brewers' run line: Milwaukee +1.5, the Cubs -9.

Milwaukee lost its first game at Wrigley Field last season but went on to win eight of its final nine at "The Friendly Confines" and outscored the Cubs 37-9 during a four-game sweep in August. Corbin Burnes was superb against Chicago in 2021, going 2-0 with three runs allowed and 36 strikeouts over 20 innings in three starts. Christian Yelich is looking to bounce back from a season in which he hit only nine home runs. Hunter Renfroe is expected to help take some of the pressure off Yelch.

Kyle Hendricks has won double digits in victories in each of his last three full seasons. Patrick Wisdom had a breakout year for the Cubs in 2021, leading the team and breaking the franchise rookie record with 28 home runs. Seiya Suzuki signed a five-year, $85 million contract with the Hiroshima Toyo Carp.

SportsLine's model is leaning over on the run total. It also says one side of the money line has all the value.