Duke vs. Notre Dame odds, line: 2023 college football picks, Week 5 predictions from proven model

The No. 11 Notre Dame Fighting Irish will try to bounce back from a crushing loss when they face the No. 17 Duke Blue Devils on Saturday night. Notre Dame lost a thriller against Ohio State with less than five seconds remaining last week, suffering its first loss of the season. Duke remained unbeaten with a 41-7 win at UConn, picking up its fourth consecutive double-digit victory. 

Kickoff is set for 7:30 p.m. ET on Saturday at Brooks Field at Wallace Wade Stadium in Durham. Notre Dame is favored by 5.5 points in the latest Duke vs. Notre Dame odds, while the over/under is set at 52 points, per SportsLine consensus. 

Before entering any Notre Dame vs. Duke picks, you NEED to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has simulated Duke vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.