Clemson vs. Notre Dame odds, line: 2022 college football picks, Week 10 predictions from proven model

Clemson Tigers are 4-point favorites against the Notre Dame Fighting Irish. The game is set for 7:30 p.m. ET on Saturday. Notre Notre has won five of its last six games. Clemson is trying to reach the College Football Playoff. SportsLine's computer model simulates every college football game 10,000 times and has returned a profit of almost $3,100 for $100 players on its top-rated college picks.

Clemson is a four-point favorite against Notre Dame. The game is scheduled for Saturday. SportsLine's computer model has made its picks for Clemson vs. Notre Notre.

Clemson vs. Notre Dame is a college football game. Clemson is favored by 4 points.

Notre Dame has suffered a few disappointing losses this season, but it has also shown that it can beat ranked teams. The Fighting Irish have picked up wins over North Carolina, BYU and Syracuse. They also held a 10-3 lead over No. 2 Ohio State in their season opener. Clemson has only faced one ranked team on the road this year, and it was in double overtime.

Clemson is on a 14-game winning streak. Notre Dame has lost three of its last four games against Clemson. Clemson has an advantage because last week was their open week. Will Shipley has been running well recently.

The model simulates Notre Dame vs. Clemson 10,000 times and it's picking Clemson to win. The model is leaning Over.