Clemson vs. Louisville odds, line, spread: 2022 college football picks, Week 11 predictions from proven model
Clemson Tigers lost at Notre Dame last week. They play Louisville Cardinals on Saturday at 3:30 p.m. ET. The Tigers are favored by 7 points. Louisville is on a four-game winning streak. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a huge profit for its players.
Clemson is playing Louisville in the college football game on Saturday. The game is a money line of Clemson -278 and Louisville -222. SportsLine's computer model has picked Clemson.
Clemson vs. Louisville is a college football game. Clemson is favored by 7 points. The game is expected to be won by Clemson.
Clemson is coming off a road loss to Notre Dame. The Tigers have won three ranked games this season. They are on a 38-game home winning streak and have never lost to Louisville in seven previous meetings.
Louisville has won four straight games to become bowl eligible. The Cardinals racked up 244 rushing yards against James Madison last week. Quarterback Malik Cunningham has amassed more than 2,000 total yards and 19 touchdowns this season.
Louisville is favored by over Clemson. The model has simulated Louisville vs. Clemson 10,000 times and it's leaning Over. It also generated a point-spread pick that's hit in almost 60% of simulations.
