Clemson vs. Notre Dame odds, line: 2022 college football picks, Week 10 predictions from proven computer model

No. 5 Clemson Tigers are trying to keep their perfect season alive when they face the Notre Dame Fighting Irish on Saturday night. Kickoff is set for 7:30 p.m. ET. Clemson had last week off after a 27-21 win over then-No 14 Syracuse two weeks ago. Notre Notre has won five of its last six games, including a 41-24 win against Syracuse last weekend. The Tigers is favored by 3.5 points in the latest Notre Irish vs. Tigers odds from Caesars Sportsbook.

Notre Dame vs. Clemson is a college football game. The money line is Notre Dame +152, Clemson -180. SportsLine's computer model has picked the game for Notre Notre.

Clemson and Notre Dame are playing each other in 2022. The game is expected to be played in 44 points.

Notre Dame has suffered a few disappointing losses this season, but it has also shown that it can beat ranked teams. The Fighting Irish have picked up wins over North Carolina, BYU and Syracuse. They also held a 10-3 lead over No. 2 Ohio State in their season opener. Clemson has only faced one ranked team on the road this year, and it was in double overtime.

Clemson is on a 10-game winning streak and has won five straight road games. The Tigers have an open date on Saturday night. DJ Uiagalelei has thrown for 1,803 yards, 17 touchdowns and four interceptions this season.

The model simulates Notre Dame vs. Clemson 10,000 times and it's picking Clemson to win. The model is leaning Over.