Florida State vs. Louisville odds, line, picks: Predictions and best bets for Friday's ACC college football matchup from proven computer model

Louisville Cardinals host Florida State Seminoles on Friday at 7:30 p.m. ET at Papa John's Cardinal Stadium in Louisville, Ky. The Seminole are 2.5-point favorites in the latest Caesars Sportsbook odds. Over/Under for total points is set at 56. Louisville beat UCF 20-14 last Friday in Orlando. FSU won 24-23 at the Superdome in New Orleans. Last year, Louisville won the game 31-24 in Tallahassee. SportsLine's computer model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,400 for $100 players on its college game picks against the spread.