Florida State vs. Louisville Picks, Predictions Week 3 College Football: ACC Foes Collide on Friday Night

Louisville and Florida State are playing each other in the first Friday night college football game of the week. Florida played LSU in Week 1 and won by one point. Louisville beat UCF in their home opener last week and is favored to beat FSU.

Bettors are backing Florida State heavily. The opening spread has shifted from FSU -1.5 to -3. Over 70% of the tickets and handle are on the Seminoles.

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Louisville is a home underdog against Florida State. The Cardinals' offense has been disappointing so far this season. Florida state won the last meeting between the two teams by 8 points. The majority of the starters are back for both teams. Louisville won last week. It's difficult to argue that FSU should suddenly be laying nearly a field goal on the road.

Louisville and Florida State are playing each other on Friday. The total is 56.5 points. Florida's defense did a fine job during the school's win over LSU. Both teams have good offenses.  Louisiana's offense was impressive in Week 2, but it's hardly viewed as a juggernaut unit.

Treshaun Ward is the top option in Florida State's running back position. He had 49 rushing yards on 16 carries against LSU. Louisville's run defense is not as intimidating as it was in 2021. Louisville gave up over 130 rushingyards per game to opponents in that year.

Louisville and Florida State play each other on Friday night at 3:33 p.m. ET.