Indiana vs. Louisville odds, line: 2023 college football picks, Week 3 predictions from proven model

The Indiana Hoosiers will square off against the Louisville Cardinals on Saturday in a non-conference matchup in Indianapolis. Indiana bounced back from a season-opening loss to No. 3 Ohio State with a 41-7 win over Indiana State. Louisville has scored nearly 100 total points in its first two games, beating Georgia Tech and Murray State. 

Kickoff is set for noon ET on Saturday at Lucas Oil Stadium. Louisville is favored by 10 points in the latest Indiana vs. Louisville odds, while the over/under is set at 50.5 points, per SportsLine consensus. 

Before entering any Louisville vs. Indiana picks, you NEED to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has simulated Indiana vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Louisville? And which side of the spread is hitting well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. If you're already a member, see the picks below!