Iowa State vs. Iowa odds, line: 2023 college football picks, Week 2 predictions from proven model

The Iowa State Cyclones and Iowa Hawkeyes will battle for bragging rights when they square off on Saturday afternoon. Iowa State has not won a home game against Iowa since 2011, but it snapped a six-game losing streak in the series with a 10-7 win over in Iowa City last year. The Hawkeyes still hold a 46-23 edge in the all-time series, though. 

Kickoff is set for 3:30 p.m. ET on Saturday at Jack Trice Stadium in Ames. Iowa is favored by 4 points in the latest Iowa State vs. Iowa odds, while the over/under is set at 36.5 points, per SportsLine consensus. 

Before entering any Iowa vs. Iowa State picks, you NEED to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. The proprietary computer model is off to a fast 4-2 start on all top-rated college football picks this season. Since its inception, it has generated a stunning profit of more than $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has simulated Iowa State vs. Iowa 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.