Kansas vs. Houston odds, line, spread: 2022 college football picks, Week 3 predictions from proven model

The Kansas Jayhawks are looking to improve to 3-0 for the first time since 2009. They beat West Virginia in overtime last week. Houston is coming off a loss to Texas Tech. The Cougars are favored by 8.5 points. SportsLine's advanced computer model simulates every FBS college football game 10,000 times and has returned huge returns for its players.

SportsLine's computer model has picked Houston vs. Kansas. The model is using a college football spread of 8.5 points.

Kansas is favored by 8.5 points. Houston is 8th.

Kansas has not won three straight games to open a season in more than a decade. Houston is going to be motivated for its home opener after beating UTSA in triple overtime and losing to Texas Tech in double overtime last week. The Cougars are an outstanding offensive team, led by senior quarterback Clayton Tune.

Kansas has been one of the most surprising teams in the country through the first two weeks of this season. The Jayhawks lead the league in points per game (55.5) and have covered the spread in five consecutive games. Houston's defense has struggled this year and has played five overtime periods in its first 2 games, so it will be difficult for them to match Kansas' energy.

The model simulates Kansas vs. Houston 10,000 times and it's picking Kansas to win. SportsLine's model is leaning Over.