Iowa State vs. Kansas odds, line: 2022 college football picks, Week 5 predictions from proven computer model

Iowa State Cyclones (3-1) will try to spoil Kansas' perfect season on Saturday afternoon. Kickoff is set for 3:30 p.m. ET. Iowa State is favored by three points in the latest Caesars Sportsbook odds. The over/under is 59. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a huge profit for its players.

SportsLine's computer model has picked Kansas vs. Iowa State. The model is using a college football spread of 3 points.

Kansas vs. Iowa State is a college football game. Kansas is favored by 3 points. The game is expected to be won by Iowa.

Kansas is looking to break into the AP Top-25 poll for the first time since 2009. The Jayhawks have already knocked off West Virginia and Houston as underdogs and beat Tennessee Tech and Duke as favorites. Kansas covered the 7-point spread in their 35-27 win over Duke last week.

Iowa State lost to Baylor last week. The Cyclones are the best defensive team that Kansas has faced this season. Hunter Dekkers has passed for more than 1,000 yards and 10 touchdowns this year. Jirehl Brock has gone over 70 yards in all four games. Iowa State has won seven straight games against Kansas.

The model has simulated Iowa State vs. Kansas 10,000 times and it's leaning Under. The model generated a point-spread pick where one side has all of the value.