Miami Dolphins vs San Francisco 49ers Odds, Lines, Spread, and Picks NFL Week 13

The Dolphins are the sixth-best scoring offense in the NFL. Tua Tagovailoa has been playing well since his return from concussion. The Dolphins have the 28th-ranked rushing game, while the 49ers have one of the best rushing defenses. Miami's offensive line is banged up, with starting tackles Terron Armstead and Austin Jackson doubtful. San Francisco's pass rush is top-10 in NFL, led by Nick Bosa.

The San Francisco 49ers are the top-scoring team in the NFL. They are also the only team to go sub-300 yards per game. The 49er's run game struggled, with 96 yards on 29 carries. Jordan Mason will replace Elijah Mitchell in place of him. Christian McCaffrey missed practice this week, but should be able to play. Deebo Samuel and Trent Williams are both listed as questionable.

The Dolphins are 5-0 ATS in their last 5 starts. The 49ers are a combined 23 games under .500 on the year. Miami's offensive line is a major deterrent. San Francisco has only allowed two teams to break the 20-point mark on this season.