Michigan State vs. Illinois Prediction, Odds, Spread and Over/Under for College Football Week 10

Illinois is the class of the Big Ten West and looks to make another big step towards doing that by winning at home against Michigan State. The Spartans were once a top 10 team about a year ago, but they are now 3-5 and lost to in-state rival Michigan 29-7.

Michigan State and Illinois are playing each other in College Football Week 10. The game is on the road. Michigan State is the healthiest team all season. Illinois is a team that isn't built to win by a large margin. The team won against Nebraska after the Cornhuskers lost their starting quarterback Casey Thompson to a wrist injury.