Minnesota Vikings vs Buffalo Bills Odds, Predictions and Best Bets for Week 10

Josh Allen missed practice all week with an injured elbow on his throwing arm. He made a brief appearance on Friday. Online sportsbooks don't expect him to play in the Week 10 NFL odds.

The Bills are 3-point favorites against the Vikings. The game is set for 1 pm ET at Highmark Stadium in Orchard Parrk, NY. There is a 40% chance of a rain-snow mix and 15 mph sustained winds.

Case Keenum will start for the Vikings against his former team Buffalo Bills. The Vikings' defense ranks 19th per DVOA and is one of the worst at defending number one receivers. Buffalo's defense has been hit hard by injuries, with Jordan Poyer, Micah Hyde and Greg Rousseau out. The Bills' offense is in good shape aside from Josh Allen.

The Vikings are 7-1 but their only win came against Miami. They are 6-0 in one-score games this season. DVOA ranks them 18th overall. Justin Jefferson is their star player. He is second in the league in receiving yards and is averaging 124 yards through the air over his past five games.

The Vikings are underdogs against the Bills. The line has gone too far for the Vikings.

Minnesota Vikings are Super Bowl odds favorites against the Buffalo Bills. The Vikings have struggled against spread this season, posting a 3-5 record. They have failed to cover against three of their four backup starters.

Buffalo Bills are betting on themselves to cover at home against Minnesota Vikings.

Minnesota Vikings vs Buffalo Bills is a game for the 2022 NFL season.