Sunday Night Football odds, spread, line: 49ers vs. Broncos prediction, NFL picks, bets from expert who's 17-6

The San Francisco 49ers and Denver Broncos are playing each other on Sunday Night Football at 8:20 p.m. ET. Both teams are 1-1 this season. The 49er's are a 1.5-point favorite. SportsLine's Tom Fornelli has gone a profitable 29-16- 1 in his last 46 NFL best bets involving the 49erners.

49ers vs. Broncos is Sunday Night Football. The game is worth 44.5 points. 49ers are 13-9 against the spread in their last 22 games. Denver is 8-11 against-the-spread in its last 19 games against teams with losing records.

49ers vs. Broncos is Sunday Night Football. The 49ers are 13-9 against the spread in their last 22 games. Denver is 8-11 against-the-spread in its last 19 games against teams.

The 49ers are the best team in total defense and pass defense. Nick Bosa is the team's best player. Denver is averaging only 16 points per game this season. The Broncos have not generated a red zone touchdown in 2022. The 49er's are a 17-6 NFL expert's pick.

The Broncos are No. 3 in the NFL in averaging 41.2 yards per drive and rank in top eight of the league in total offense. Denver is keyed by Russell Wilson, who is a nine-time Pro Bowl quarterback with more than 3,000 passing yards in every season of his career. He is also 17-4 all- time against the 49ers dating back to his time with the Seahawks.

Fornelli is a 17-6 expert who has analyzed the 49ers vs. Broncos game. Fornelli has found a critical X-factor that has him jumping all over one side of the spread.