Rams vs. 49ers odds, spread, line: Monday Night Football picks, predictions by top NFL model on 139-103 run

The Los Angeles Rams and San Francisco 49ers are playing on Monday Night Football. The Rams beat the Arizona Cardinals 20-12 last week. San Fran. fell to Denver Broncos 11-10 last time out. Both teams covered the spread once this season. The over/under is 42.5 points.

Rams vs. 49ers is Monday Night Football. The Rams are 4-1 ATS in their last five Monday night games. SportsLine's advanced computer model has picked Rams to win.

Rams vs. 49ers money line is Los Angeles +105, San Francisco -125. Rams are 4-1 ATS in their last five Monday Night Football games.

The 49ers are ranked sixth in rushing yards per game (151) and are logging 4.5 yards a carry. Jeff Wilson Jr. is leading the team with 39 carries for 181 yards and 4:6 yards. Deebo Samuel is a receiver with breakaway speed and good hands.

Matthew Stafford is completing 72% of his throws for 761 yards with four passing touchdowns. Cooper Kupp is a true No. 1 receiver. Kpp ranks second in catches (28), eighth in receiving yards (280) and tied for second with 3 receiving touchdowns (3).

The model is leaning Under on the total and says one side of the spread hits well over 50% of time. Rams vs. 49ers is on Monday Night Football.