NFL Upset Picks, Predictions: Top Underdog Picks for Week 15

The top five underdogs won their games in Week 14. The biggest favorites went 5-0. Dallas needed a last-minute touchdown to beat Houston and Kansas City nearly coughed up a 27- 0 lead over Denver.

Jacksonville Jaguars are the top underdog pick for NFL's Week 15. Pittsburgh Steelers are second favorite pick. New York Giants are third favorite.

Jacksonville Jaguars are the top underdog pick for NFL's Week 15. Pittsburgh Steelers are also a top pick.

Jaguars won for the first time in Tennessee since 2013. The Jaguars defense had four takeaways and scored 20 points off those takeovers. Trevor Lawrence has thrown 10 touchdown passes and no interceptions over the last five games. Dallas has started slowly in its previous three games and has scored 37.3 ppg during a four-game winning streak.

Pittsburgh Steelers are 55-26-2 straight up since drafting T.J. Watt in 2017. Carolina Panthers are 4-4 in their last 8 games and are in control of their own destiny to claim the NFC South. Sam Darnold is one of two quarterbacks with two-plus wins and zero losses.

Giants and Cowboys play each other for the second time in three weeks. The first game ended in a tie. Giants are 0-3-1 in division games this year and are winless in their last seven against NFC East opponents. Daniel Jones is 15-7 against the spread and 24-15 as an underdog.

NFL Upset Picks, Predictions: Top Underdog Picks for Week 15 are made 12/13/2022 at 6:22 a.m. ET.