NFL Upset Picks, Predictions: Top Underdog Picks for Week 6

The trend of underdog wins in the NFL continued in Week 5. New York Giants and Houston Texans upset the Green Bay Packers and Jacksonville Jaguars. Seven of the 14 games on this week's slate have point spreads of afield goal or less.

Saints are the favorite to beat Bengals. New Orleans scored 39 points last week despite not having Jameis Winston, Michael Thomas, or Jarvis Landry available. Andy Dalton is the new Bengals starting quarterback. Taysom Hill has been spectacular at quarterback for the Saints. Bengals are last in the league with a minus-8 turnover differential.

The Jaguars are 2-point underdogs to the Colts. The home team has won the last 10 meetings between the teams. Indianapolis is averaging just 13.8 points per game. If Jonathan Taylor is injured for a second straight game, the team may not score.

Chiefs have beaten the Bills in three of the last four meetings dating back to 2020. The previous two playoff games were played at Arrowhead Stadium. Patrick Mahomes is 7-0-1 against the spread as an underdog.

NFL Upset Picks, Predictions: Top Underdog Picks for Week 6 were made 10/11/2022 at 5:38 a.m. ET.