Ohio State vs. Michigan State odds, line: 2022 college football picks, Week 6 predictions from proven model

The Michigan State Spartans host the No. 3 Ohio State Buckeyes on Saturday at 4 p.m. ET. Michigan is on a three-game losing streak and the Buckeye's are favored by 27 points. The over/under is set at 65. SportsLine's college football prediction model simulates every game 10,000 times and has returned a profit of more than $3,100 for $100 players on its top-rated college game picks.

Ohio State vs. Michigan State is a college football game. The game is scheduled for Saturday. There are college odds for Michigan vs Ohio State.

Ohio State vs. Michigan State is a college football game. The line is Michigan state -27. Ohio State has a 65-point favorite.

Michigan State is a 27-point favorite against Ohio State. The Buckeyes have lost three straight games by double digits. Michigan State has won eight of its last nine home games. Ohio state is playing on the road for the first time this season.

Ohio State has the top scoring offense in the country, averaging 48.8 points per game. TreVeyon Henderson is expected to return after missing last week's game with an injury. Wide receiver Jaxon Smith-Njigba is also expected back. Ohio State won eight consecutive games at Michigan State and picked up a 56-7 win over the then-No. 7 ranked Spartans at home last season.

The model simulates Ohio State vs. Michigan State 10,000 times and it's picking the Under. The model has also generated a point-spread pick that's hitting in well over 50% of simulations.