Ohio State vs. Northwestern prediction, odds: 2022 Week 10 college football picks, best bets from proven model

Ohio State Buckeyes are 8-0 and the No. 2 seed in the College Football Playoff Rankings for the 2022 season. They play Northwestern Wildcats (1-7, 1-4) at noon on Saturday. The Buckeye are 38-point favorites. Northwestern has lost seven straight games. SportsLine's advanced computer model simulates every FBS college football game 10,000 times. It has returned a huge profit for $100 players on its top-rated collegeFootball picks.

Ohio State is a 38-point favorite against Northwestern. The Wildcats have covered the spread in three of their past five conference games as a double-digit underdog. Ohio State's road team is 5-1 against the odds in the last six meetings in this rivalry.

Ohio State is averaging 49 points per game. The team is ranked No. 4 nationally. C.J. Stroud has completed 70.3% of his passes for 2,377 yards and 29 touchdowns against four interceptions. Ohio State has a tough final stretch, including a trip to Maryland and a game against Michigan.

Northwestern beat Nebraska 31-28 in their season opener. The Wildcats have been inconsistent this season, but they have managed to stay competitive in most games. They have a conservative defensive approach designed to prevent big plays and force opponents to slowly drive the length of the field. Ohio State is favored by four points.

SportsLine's model is leaning Over on the total. It projects a combined 58 points for Northwestern and Ohio State. One side of the spread hits in well over 60% of simulations.